Bicyclic diamines as janus kinase inhibitors

US8937077B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• David Joseph Guerin · Natick, US
• Jason D. Brubaker · Cambridge, US
• Michelle Martinez · Salem, US
• Joon Jung · Newton, US
• Neville J. Anthony · Hatfield, US
• Mark E. Scott · Fairfield, US
• Carolyn Michele Cammarano · Newton, US
• Dawn Marie Hoffman · Boston, US
• Hyun Chong Woo · Natick, US
• Christopher J. Dinsmore · Schwenksville, US
• Philip Jones · Houston, US

Key dates

• Filing date: Oct 17, 2011
• Grant date: Jan 20, 2015
• Expiry date: Nov 9, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.