Bispecific, bivalent anti-VEGF/anti-ANG-2 antibodies

US8945552B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Monika Baehner · Munich, DE
• Sabine Imhof-Jung · Planegg, DE
• Anita Kavlie · Oslo, NO
• Hubert Kettenberger · Munich, DE
• Christian Klein · Iffeldorf, DE
• Joerg THOMAS · Munich, DE
• Wolfgang Schaefer · Sankt Augustin, DE
• Kay-Gunnar Stubenrauch · Frauenfeld, CH
• Markus Thomas · Rheinfelden (Baden), DE

Key dates

• Filing date: Mar 24, 2011
• Grant date: Feb 3, 2015
• Expiry date: Mar 2, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.