Methods and compositions for modification of a HLA locus

US8945868B2 · kind B2 · utility

Assignees

• Sangamo Biosciences, Inc. · US
• The Board of Regents of the University of Texas System · US

Inventors

• Trevor Collingwood · Chesterfield, US
• Laurence J.N. COOPER · Houston, US
• Philip D. Gregory · Richmond, US
• Michael C. Holmes · Richmond, US
• Jeffrey C. Miller · Pleasanton, US
• Edward J. Rebar · Richmond, US
• Andreas Reik · Richmond, US
• Fyodor Urnov · Richmond, US

Key dates

• Filing date: Jul 21, 2011
• Grant date: Feb 3, 2015
• Expiry date: Sep 25, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.