Patent · US Active

Compositions and methods for modulation of SMN2 splicing

US8946183B2 · kind B2 · utility

10Cited by

16References

14Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Brenda F. Baker · Carlsbad, US
Adrian R. Krainer · Huntington Station, US
Yimin Hua · Los Altos, US

Key dates

Filing date	Dec 19, 2012
Grant date	Feb 3, 2015
Priority date	—
Expiry date	Feb 2, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/33
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.