Inhibitors of the renal outer medullary potassium channel

US8952166B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Fa-Xiang Ding · Staten Island, US
• Shuzhi Dong · Plainsboro, US
• Jessica Frie · Harleysville, US
• Xin Gu · Scotch Plains, US
• Jinlong Jiang · Scotch Plains, US
• Alexander Pasternak · Brookline, US
• Haifeng Tang · South San Francisco, US
• Zhicai Wu · Montvale, US
• Yang Yu · Jinan, CN
• Takao Suzuki · Shanghai, CN

Key dates

• Filing date: Jul 25, 2013
• Grant date: Feb 10, 2015
• Expiry date: Jul 25, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula Iand the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.