Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment

US8957062B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Scott D. Edmondson · Hoboken, US
• Zhiqiang Guo · San Diego, US
• Harold B. Wood · Westfield, US
• Andrew Stamford · Madison, US
• Michael Miller · Scotch Plains, US
• Duane DeMong · Somerville, US
• Gregori J. Morriello · Dover, US
• Rajan Anand · Wilmington, US
• Vincent J. Colandrea · New Brunswick, US
• Megan Macala · Westfield, US
• Milana Maletic · Summit, US
• Cheng Zhu · Edison, US
• Yuping Zhu · Edison, US
• Wanying Sun · Edison, US
• Kake Zhao · Westfield, US
• Yong Huang · Plainsboro, US
• Joel M. Harris · Summit, US
• Lehua Chang · Ramsey, US
• Nam Fung Kar · Brooklyn, US
• Zhiyong Hu · Livingston, US
• Liping Wang · Plainsboro, US
• Bowei Wang · Westfield, US
• Ping Liu · Shanghai, CN
• Jason W. Szewczyk · Collegeville, US
• William B. Geiss · Athens, US

Key dates

• Filing date: Apr 5, 2012
• Grant date: Feb 17, 2015
• Expiry date: Apr 5, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.