Binding polypeptides and uses thereof
US8957187B2 · kind B2 · utility
1Cited by
82References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 1, 2006 |
| Grant date | Feb 17, 2015 |
| Priority date | — |
| Expiry date | Oct 23, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/71
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides antibodies or antigen binding fragments thereof to DR5 and HER-2. The antibodies and/or antigen binding fragments thereof comprise variant CDRs comprising highly restricted amino acid sequence diversity. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. In addition, compositions and methods of use for treatment of cancer and immune related conditions are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.