Antibodies that bind GalNAc1-3Gal, pharmaceutical compositions and methods of using same

US8957188B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Jeffrey Gildersleeve · Frederick, US
• Zhitao Li · Lo Wu, CN
• Qian Li · Sydney, AU
• Miriam Anver · Rectortown, US
• Donna O. Butcher · Kearneysville, US

Key dates

• Filing date: Apr 1, 2010
• Grant date: Feb 17, 2015
• Expiry date: Feb 4, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2400/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Monoclonal antibodies to carbohydrate antigens containing a terminal GalNAcα1-3Gal are provided. The antibodies of the present invention are found to specifically recognize GalNAcα1-3Gal with little cross-reactivity to other structurally similar antigens such as GalNAcα1-6Gal, blood group A, Forssman antigen and the Tn antigen on both solution assays and human tissue. Compositions comprising the monoclonal antibodies, as well as methods of diagnosis, treatment and prognostication are also provided.