Modulators of amyloid beta

US8962834B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Karlheinz Baumann · Weil am Rhein, DE
• Alexander Flohr · Basel, CH
• Erwin Goetschi · Reinach, CH
• Helmut Jacobsen · Schopfheim, DE
• Synese Jolidon · Blauen, CH
• Thomas Luebbers · Soest, DE

Key dates

• Filing date: Jan 25, 2013
• Grant date: Feb 24, 2015
• Expiry date: Mar 7, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of formulawherein the substituents are as described in claim 1. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.