Patent · US Active

Substituted nucleotide analogs

US8980865B2 · kind B2 · utility

76Cited by

152References

24Claims

0Family size

Assignee

ALIOS BIOPHARMA, INC. · US

Inventors

Guangyi Wang · Carlsbad, US
Leonid Beigelman · San Mateo, US

Key dates

Filing date	Dec 20, 2012
Grant date	Mar 17, 2015
Priority date	—
Expiry date	Jan 4, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H19/207
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate prodrugs and thiophosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates and methods of treating viral infections, such as HCV, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.