Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting

US8993295B2 · kind B2 · utility

Assignee

• The General Hospital Corporation · US

Inventors

• Brian Seed · Boston, US
• Jia Liu Wolfe · Winchester, US
• Glen S. Cho · Brookline, US
• Chia-Iun Tsai · Winchester, US

Key dates

• Filing date: Jul 20, 2007
• Grant date: Mar 31, 2015
• Expiry date: Oct 20, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for treating various diseases through selective killing of targeted cells using a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting moiety and, a modifiable activation moiety which is activated by an activation moiety not naturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population.