Tropolone compounds for treating or preventing retroviral infection

US8993768B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• John A. Beutler · Braddock, US
• Stuart F. J. LeGrice · Poolesville, US
• Craig J. Thomas · Gaithersburg, US
• Jian-Kang Jiang · Columbia, US
• Suhman Chung · Lasów Chojnowskich, US
• Jennifer H. Wilson · Frederick, US

Key dates

• Filing date: May 10, 2012
• Grant date: Mar 31, 2015
• Expiry date: May 10, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds that inhibit RNase H activity of retroviruses, for example, a compound of formula (I) wherein R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment or prevention of infection by human immunodeficiency virus (HIV).