Systems and methods for manufacturing liposomes
US9005654B2 · kind B2 · utility
14Cited by
16References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 27, 2006 |
| Grant date | Apr 14, 2015 |
| Priority date | — |
| Expiry date | Dec 25, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. A therapeutic agent, such as nucleic acid, is included in one of the buffer solution or the lipid solution. Upon mixing a liposome encapsulating the therapeutic product is substantially instantaneously formed. Thereafter the liposome solution formed is immediately diluted with buffer solution to enhance homogeneity and maintain small particle size.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.