Patent · US Active

Determination of KIR haplotypes associated with disease

US9005894B2 · kind B2 · utility

52Cited by

3References

12Claims

0Family size

Assignees

Roche Molecular Systems, Inc. · US
Children's Hospital & Research Center at Oakland · US
Conexio Genomics Pty Ltd · AU

Inventors

Martha B. Ladner · Oakland, US
Elizabeth Trachtenberg · Oakland, US
Lloyd Gordon Bentley · Alameda, US
Damian Goodridge · Sydney, AU
Henry A. Erlich · Oakland, US

Key dates

Filing date	Sep 17, 2010
Grant date	Apr 14, 2015
Priority date	—
Expiry date	Sep 17, 2030

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A90/10
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed is a method of determining KIR genotypes for one or more individuals in parallel, the method comprising: for each individual, amplifying the polymorphic exon sequences of the KIR genes, pooling the KIR amplicons, performing emulsion PCR followed by pyrosequencing in parallel to determine all the amplicon sequences present in the individual to determine which KIR alleles are present in the individual.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.