Patent · US Active

Induction of pluripotent cells

US9005968B2 · kind B2 · utility

13Cited by
7References
24Claims
0Family size

Assignee

Inventors

Key dates

Filing dateOct 15, 2010
Grant dateApr 14, 2015
Priority date—
Expiry dateOct 15, 2030

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2510/00
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.