Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation

US9012450B2 · kind B2 · utility

Assignees

• Global Blood Therapeutics, Inc. · US
• CYTOKINETICS, INC. · US
• The Regents of the University of California · US

Inventors

• Brian W. Metcalf · Moraga, US
• Chihyuan Chuang · Millbrae, US
• Jeffrey Warrington · San Mateo, US
• Kumar Paulvannan · San Jose, US
• Matthew P. Jacobson · San Francisco, US
• Lan Hua · Mountain View, US
• Bradley P. Morgan · Moraga, US

Key dates

• Filing date: Dec 28, 2012
• Grant date: Apr 21, 2015
• Expiry date: Dec 28, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.