Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation

US9018210B2 · kind B2 · utility

Assignees

• Global Blood Therapeutics, Inc. · US
• CYTOKINETICS, INC. · US
• The Regents of the University of California · US

Inventors

• Brian W. Metcalf · Moraga, US
• Chihyuan Chuang · Millbrae, US

Key dates

• Filing date: Dec 28, 2012
• Grant date: Apr 28, 2015
• Expiry date: Dec 28, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.