Inhibitors of the renal outer medullary potassium channel

US9018211B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Alexander Pasternak · Brookline, US
• Yuping Zhu · Edison, US
• Aurash Shahripour · Rahway, US
• Haifeng Tang · South San Francisco, US
• Lihu Yang · Edison, US
• Shawn P. Walsh · Bound Brook, US
• Nardos Teumelsan · Linden, US

Key dates

• Filing date: Jan 24, 2014
• Grant date: Apr 28, 2015
• Expiry date: Jan 24, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds having structural Formula I:and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.