Fluoro-substituted 2-aryl-3,5-dicyano-4-indazolyl-6-methyl-1,4-dihydropyridines and uses thereof

US9018234B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Alexandros Vakalopoulos · Hilden, DE
• Martin Michels
• Katja Zimmermann · Mülheim an der Ruhr, DE
• Nicole Teusch · Uerdingen, DE
• Mario Lobell · Wuppertal, DE
• Karen Engel · Waldkraiburg, DE

Key dates

• Filing date: Nov 8, 2010
• Grant date: Apr 28, 2015
• Expiry date: Nov 14, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel, fluoro-substituted 2-aryl-3,5-dicyano-4-(1H-indazol-5-yl)-6-methyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer and other proliferative disorders.