Optimized Fc variants

US9051373B2 · kind B2 · utility

Assignee

• Xencor, Inc. · US

Inventors

• Gregory Alan Lazar · Los Angeles, US
• Wei Dang · Pasadena, US
• John Desjarlais · Pasadena, US
• Sher Bahadur Karki · Pasadena, US
• Omid Vafa · Monrovia, US
• Robert Hayes · Paoli, US
• Jost Vielmetter · Altadena, US

Key dates

• Filing date: Feb 11, 2013
• Grant date: Jun 9, 2015
• Expiry date: Feb 11, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/734
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to a variant Fc region comprising an amino acid substitution at position 238 of the Fc region as compared to a human parent Fc region, wherein the variant Fc region comprises a 238D substitution, wherein the variant Fc region binds FcγRIIb with increased binding affinity compared to a human parent Fc region.