Inhibitors of the renal outer medullary potassium channel

US9056859B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Alexander Pasternak · Brookline, US
• Reynalda K. DeJesus · East Brunswick Township, US
• Yuping Zhu · Edison, US
• Lihu Yang · Edison, US
• Shawn P. Walsh · Bound Brook, US
• Haifeng Tang · South San Francisco, US
• Dooseop Kim · Scotch Plains, US
• Barbara Pio · West Orange, US
• Aurash Shahripour · Rahway, US
• Kevin M. Belyk · Metuchen, US

Key dates

• Filing date: Oct 24, 2011
• Grant date: Jun 16, 2015
• Expiry date: Oct 24, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds having structural Formula (I); and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir 1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.