Deuterated benzylbenzene derivatives and methods of use

US9061060B2 · kind B2 · utility

Assignee

• Theracos, Inc. · US

Inventors

• Brian Seed · Boston, US
• Binhua Lv · 安丰镇, CN
• Jacques Y. Roberge · Princeton, US
• Yuanwei Chen · Sichuan, CN
• Kun Peng · Shanghai, CN
• Jiajia Dong · Beijing, CN
• Baihua Xu · Shanghai, CN
• Jiyan Du · Shanghai, CN
• Lili Zhang · Colonia, US
• Xinxing Tang · Shanghai, CN
• Ge Xu · Columbia, US
• Yan Feng · Chengdu, CN
• Min Xu · Lo Wu, CN

Key dates

• Filing date: Jul 15, 2009
• Grant date: Jun 23, 2015
• Expiry date: Jun 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D309/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.