Variants in complement regulatory genes predict age-related macular degeneration

US9063139B2 · kind B2 · utility

Assignees

• The Trustees of Columbia University in the City of New York · US
• University of Iowa Research Foundation · US
• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Rando Allikmets · Frederick, US
• Gregory S. Hageman · Coralville, US
• Michael Dean · Frederick, US
• Albert M. Gold · Frederick, US

Key dates

• Filing date: Aug 2, 2011
• Grant date: Jun 23, 2015
• Expiry date: Aug 24, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/164
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided.