Oxadiazolo[3,2-a]pyrimidines and thiadiazolo[3,2-a]pyrimidines

US9066948B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• The Rockefeller University · US
• ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · US

Inventors

• Barry S. Coller · New York, US
• Craig J. Thomas · Gaithersburg, US
• Marta Filizola · Yonkers, US
• Joshua McCoy · Portland, US
• Wenwei Huang · Rockville, US
• Min-Jui Richard Shen · Boyds, US

Key dates

• Filing date: Jul 15, 2011
• Grant date: Jun 30, 2015
• Expiry date: Jan 3, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula P-1 and related compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The definitions of A, Y, R1, R2, Ra, Ra′, Rb, Rb′, Rc, Rc′, Rd, Rd′, Re, and Re′ are provided herein. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.