Inhibitors of the renal outer medullary potassium channel

US9073882B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Haifeng Tang · South San Francisco, US
• Alexander Pasternak · Brookline, US
• Lihu Yang · Edison, US
• Shawn P. Walsh · Bound Brook, US
• Barbara Pio · West Orange, US
• Aurash Shahripour · Rahway, US
• Nardos Teumelsan · Linden, US

Key dates

• Filing date: Oct 21, 2011
• Grant date: Jul 7, 2015
• Expiry date: Oct 21, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds having structural Formula I:and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.