Benzoxazepin compounds selective for PI3K P110 delta and methods of use
US9090628B2 · kind B2 · utility
1Cited by
14References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 20, 2012 |
| Grant date | Jul 28, 2015 |
| Priority date | — |
| Expiry date | Nov 6, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.