Inhibitors of hepatitis C virus replication

US9090661B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Craig A. Coburn · Royersford, US
• John A. McCauley · Maple Glen, US
• Steven W. Ludmerer · North Wales, US
• Kun Liu · Edison, US
• Joseph P. Vacca · Telford, US
• Hao Wu · Shanghai, CN
• Bin Hu · Mesa, US
• Richard Soll · San Diego, US
• Fei Sun · Shanghai, CN
• Xinghai Wang · Shanghai, CN
• Man Yan · Shanghai, CN
• Chengren Zhang · Shanghai, CN
• Mingwei Zheng · Shanghai, CN
• Bin Zhong · Shanghai, CN
• Jian Zhu · Tangxia, CN

Key dates

• Filing date: Aug 29, 2014
• Grant date: Jul 28, 2015
• Expiry date: Aug 29, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.