Protection and treatment against influenza infection

US9095579B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Ethan Bier · San Diego, US
• Margery Smelkinson · San Diego, US
• Robert M. Krug · Austin, US
• Meghana Malur · Austin, US
• Michael Oldstone · Village of La Jolla, US
• John Teijaro · San Diego, US

Key dates

• Filing date: Feb 7, 2013
• Grant date: Aug 4, 2015
• Expiry date: Mar 30, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Method and composition for protection and treatment against influenza viral infection by modulating the activity of at least one essential host signaling pathways, including the Hedgehog (Hh), the Bone Morphogenetic Protein (BMP), the Notch (N) signaling pathways or combinations thereof, which activity is altered by the viral protein NS1. The method and composition comprise use of a compound that modulates at least one of these essential host signaling pathways for preventing or controlling symptoms associated with influenza viral infection. The method or composition can also be used either alone or in combination with other therapeutic agents for treating or protecting against influenza infection, and associated syndromes.