Azaindoles as Janus kinase inhibitors

US9096598B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• John W. Butcher · Telford, US
• David J. Witter · Norfolk, US
• Christopher J. Dinsmore · Schwenksville, US
• June J. Kim · West Chester, US
• John Hendrix · Charlottesville, US
• Raksha Archarya · Bedford, US
• Sean P. Ahearn · Somerville, US
• Joon Jung · Newton, US
• Alexey Rivkin · Emeryville, US
• Philip Jones · Houston, US

Key dates

• Filing date: Sep 28, 2012
• Grant date: Aug 4, 2015
• Expiry date: Sep 28, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.