Chimeric oligomeric compounds and their use in gene modulation
US9096636B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 4, 2003 |
| Grant date | Aug 4, 2015 |
| Priority date | — |
| Expiry date | Mar 13, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes at least one nucleotide comprising a chimeric organic composition. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide comprising a chimeric organic composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.