Method of inhibiting ABCG2 and related treatments

US9114102B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Curtis J. Henrich · Rockville, US
• Heidi R. Bokesch · Frederick, US
• Susan E. Bates · Bethesda, US
• Robert W. Robey · Laurel, US
• Suneet Shukla · Rockville, US
• Suresh V. Ambudkar · Gaithersburg, US
• Michael Dean · Frederick, US
• James B. McMahon · Frederick, US

Key dates

• Filing date: Nov 5, 2008
• Grant date: Aug 25, 2015
• Expiry date: Jan 8, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.