Heterocycle-substituted piperazino-dihydrothienopyrimidines

US9115142B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Pascale Pouzet · Biberach, DE
• Ralf Anderskewitz · Laupheim, DE
• Horst Dollinger · Schemmerhofen, DE
• Dennis Fiegen · Biberach an der Riß, DE
• Thomas Fox · Biberach, DE
• Rolf Goeggel · Ulm, DE
• Christoph Hoenke · Ingelheim am Rhein, DE
• Domnic Martyres · Biberach, DE
• Peter Nickolaus · Warthausen, DE
• Klaus Klinder · Oggelshausen, DE

Key dates

• Filing date: Dec 19, 2013
• Grant date: Aug 25, 2015
• Expiry date: Dec 20, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dihydrothienopyrimidinesulphoxides of formula 1wherein X is SO or SO2, R1 is H or C1-6-alkyl, R2 is H or an organic group as disclosed herein, and R3 is an optionally substituted, mono- or bicyclic, unsaturated, partially saturated or saturated heterocycle or an optionally substituted, mono- or bicyclic heteroaryl, and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions which contain these compounds. These dihydrothienopyrimidinesulphoxides are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system, or cancers.