Monospecific and bispecific human monoclonal antibodies targeting insulin-like growth factor II (IGF-II)

US9127056B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Dimiter S. Dimitrov · Frederick, US
• Weizao Chen · Frederick, US
• Yang Feng · Frederick, US

Key dates

• Filing date: Oct 16, 2012
• Grant date: Sep 8, 2015
• Expiry date: Oct 16, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Monoclonal antibodies (mAbs), antigen binding fragments and engineered antibody domains (eAds) that specifically bind IGF-II are disclosed herein. In some embodiments, these mAbs and eAds are included in a bispecific mAb. In some embodiments, the bispecific antibody specifically binds two different epitopes of IGF-II. Methods of using these mAbs, antigen binding fragments, and eAds, bispecific antibodies, and nucleic acids encoding these mAbs, antigen binding fragments, and eAds, bispecific antibodies are also disclosed.