Bicyclic dihydroisoquinoline-1-one derivatives
US9133158B2 · kind B2 · utility
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56Claims
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Key dates
| Filing date | Nov 29, 2012 |
| Grant date | Sep 15, 2015 |
| Priority date | — |
| Expiry date | Nov 29, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/113
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides novel compounds having the general formula (I)wherein R1, R2, R3, R4, R5, R6, A1, A2, A3, A4, A5 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful, for example, as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.