FXR (NR1H4) binding and activity modulating compounds

US9139539B2 · kind B2 · utility

Assignee

• Gilead Sciences, Inc. · US

Inventors

• Olaf Kinzel · Heidelberg, DE
• Christoph Steeneck · Dossenheim, DE
• Claus Kremoser · Heidelberg, DE

Key dates

• Filing date: Jul 12, 2012
• Grant date: Sep 22, 2015
• Expiry date: Jul 12, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.