Inhibitors of the Renal Outer Medullary Potassium channel

US9139585B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Shawn P. Walsh · Bound Brook, US
• Alexander Pasternak · Brookline, US
• Reynalda K. DeJesus · East Brunswick Township, US
• Haifeng Tang · South San Francisco, US
• Barbara Pio · West Orange, US
• Aurash Shahripour · Rahway, US
• Kevin M. Belyk · Metuchen, US
• Harry R. Chobanian · Kenilworth, US
• Yan Guo · Westfield, US
• Jessica Frie · Harleysville, US
• Zhi-Cai Shi · Monmouth Junction, US
• Helen Chen · Livingston, US
• Timothy A. Blizzard · Middletown, US
• Brian Cato · Secaucus, US

Key dates

• Filing date: Oct 25, 2012
• Grant date: Sep 22, 2015
• Expiry date: Oct 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of Formula I-VI having the following general structure:and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.