2′-cyano substituted nucleoside derivatives and methods of use thereof useful for the treatment of viral diseases

US9150603B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Vinay M. Girijavallabhan · Woburn, US
• F. George Njoroge · Hackettstown, US
• Stephane L. Bogen · Somerville, US
• Angela Dawn Kerekes · Plainfield, US
• Frank Bennett · Piscataway, US
• Ying Huang · Berkeley Heights, US
• Latha G. Nair · Edison, US
• Dmitri Pissarnitski · Scotch Plains, US
• Vishal Verma · San Francisco, US
• Qun Dang · Westfield, US
• Ian Davies · Princeton, US
• David B. Olsen · Johnstown, US
• Andrew Stamford · Madison, US
• Joseph P. Vacca · Telford, US

Key dates

• Filing date: Apr 11, 2012
• Grant date: Oct 6, 2015
• Expiry date: Apr 11, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to 2′-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Cyano Substituted Nucleoside Derivative, and methods of using the 2′-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.