Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof

US9150656B2 · kind B2 · utility

Assignee

• Macrogenics, Inc. · US

Inventors

• Leslie S. Johnson · Travilah, US
• Paul A. Moore · North Potomac, US
• Ling Huang · Bethesda, US
• Deryk T. Loo · Belmont, US
• Francine Zhifen Chen · San Francisco, US

Key dates

• Filing date: Mar 1, 2011
• Grant date: Oct 6, 2015
• Expiry date: Aug 16, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.