Hybrid diazeniumdiolated compounds, pharmaceutical compositions, and method of treating cancer

US9168266B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Anna E. Maciag · Frederick, US
• Larry K. Keefer · Bethesda, US
• Joseph E. Saavedra · Thurmont, US
• Xinhua Ji · Frederick, US
• Vandana Kumari · Frederick, US

Key dates

• Filing date: Oct 18, 2012
• Grant date: Oct 27, 2015
• Expiry date: Oct 18, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are hybrid compounds that release both nitric oxide and a moiety that inhibits poly (ADP-ribose) polymerase (PARP), e.g., a compound or a pharmaceutically acceptable salt thereof of formula (I), wherein R1-4 and m-p are as described herein. Also disclosed are pharmaceutical compositions and methods of use including treating cancer and enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.