Process for making CGRP receptor antagonists
US9174989B2 · kind B2 · utility
15Cited by
1References
11Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 12, 2013 |
| Grant date | Nov 3, 2015 |
| Priority date | — |
| Expiry date | Mar 12, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The disclosure encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, having less steps and improved yields as compared to previous synthetic methods for making these compounds, which are CGRP receptor antagonists, useful for the treatment of migraine. Conditions for an amide bond formation between an acid and amine include for example reacting the compounds of Formulae B (after salt break) and C with an amide coupling reagent and optionally an additive and an acid and/or a base in a non-reactive solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.