Human soluble receptor for advanced glycation end products (sRAGE), methods of preparing human sRAGE, and treatment methods using sRAGE

US9175062B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Li Lin · New Taipei, TW
• Sungha Park · Suwon-si, KR
• Wen-Chi Wei · Cockeysville, US
• Rui-Ping Xiao · Baltimore, US
• Mark I. Talan · Baltimore, US
• Edward G. Lakatta · Bel Air, US

Key dates

• Filing date: Jan 3, 2013
• Grant date: Nov 3, 2015
• Expiry date: Jan 3, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/705
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides a method for recombinant production of human sRAGE in mammalian cells, as well as a human sRAGE having a mammalian post-translational modification and compositions thereof. The present disclosure also provides a method of treating a vascular disease, injury, or inflammation in a mammal by administering to a mammal with a vascular disease, injury, or inflammation a composition comprising human sRAGE having a mammalian post-translational modification, thereby treating the vascular disease, injury, or inflammation in the mammal.