Compounds for improved stem cell differentiation into hepatocytes
US9181218B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | Feb 3, 2015 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Feb 3, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/45
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein R1-R11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are useful in differentiating stem cells into more mature or adult-like hepatocytes for use as drug screening platforms and in disease modeling applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.