TEM8 antibodies, conjugates thereof, and their use

US9181340B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• Novartis AG · CH

Inventors

• Brad St. Croix · Frederick, US
• Tony Fleming · Stow, US
• Amit K. Chaudhary · Midland, US
• Saurabh Saha · Wellesley, US
• Xiaoyan Zhang · Lexington, US
• Rou-Fun Kwong · Cambridge, US
• Mary Beth Hilton · Thurmont, US

Key dates

• Filing date: Jun 13, 2012
• Grant date: Nov 10, 2015
• Expiry date: Jun 13, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antibodies that specifically bind TEM8 protein, and conjugates thereof, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.