Tetranectin-apolipoprotein A-I, lipid particles containing it and its use

US9187550B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Martin Bader · Penzberg, DE
• Monika Baehner · Munich, DE
• Juergen Fingerle · Kandern, DE
• Ulrich Kohnert · Habach, DE
• Jean-Luc Mary · Orsay, FR
• Silke Mohl · Basel, CH

Key dates

• Filing date: Aug 25, 2011
• Grant date: Nov 17, 2015
• Expiry date: Aug 25, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/73
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70% sequence identity with the selected sequence.