Diazeniumdiolated compounds, pharmaceutical compositions, and method of treating cancer

US9205091B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Anna E. Maciag · Frederick, US
• Larry K. Keefer · Bethesda, US
• Joseph E. Saavedra · Thurmont, US
• Lucy M. Anderson · Catonsville, US
• Harinath Chakrapani · Pune, IN

Key dates

• Filing date: Nov 12, 2010
• Grant date: Dec 8, 2015
• Expiry date: Mar 12, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method of treating cancer in a patient comprising administering to the patient an effective amount of a diazeniumdiolated (N2O2-containing) compound or a pharmaceutically acceptable salt thereof, wherein the cancer cell has an elevated level of reactive oxygen species (ROS) and/or a decreased level of one or more of PRX1, PRX6, and OGG1, compared to a normal cell of the same tissue or tissue type. An example of a diazeniumdiolated compound is Formula (I), wherein X and Q are defined herein. Also disclosed are diazeniumdiolated compounds, pharmaceutical compositions, and methods of use including enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.