Anilinopiperazine derivatives and methods of use thereof

US9206142B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Gerald W. Shipps, Jr. · Stoneham, US
• Cliff C. Cheng · Cambridge, US
• Xiaohua Huang · Qingdao, CN
• Thierry Olivier Fischmann · Scotch Plains, US
• Jose S. Duca · Cranford, US
• Matthew Richards · Somerville, US
• Hongbo Zeng · Westford, US
• Binyuan Sun · Sharon, US
• Panduranga Adulla P. Reddy · Walpole, US
• Tzu-Tshin Wong · Belmont, US
• Praveen K. Tadikonda · Norwood, US
• M. Arshad Siddiqui · Newton, US
• Marc A. Labroli · West Point, US
• Cory Seth Poker · Bound Brook, US
• Timothy J. Guzi · Chatham, US

Key dates

• Filing date: Oct 29, 2007
• Grant date: Dec 8, 2015
• Expiry date: Mar 25, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.