Pyrazole compounds as CRTH2 antagonists

US9206164B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Domnic Martyres · Biberach, DE
• Ralf Anderskewitz · Laupheim, DE
• Christoph Hoenke · Ingelheim am Rhein, DE
• Jan Kriegl · Ulm, DE
• Thorsten Oost · Biberach an der Riß, DE
• Wolfgang Rist · Ingelheim am Rhein, DE
• Peter Seither · Biberach an der Riß, DE

Key dates

• Filing date: Mar 15, 2012
• Grant date: Dec 8, 2015
• Expiry date: Oct 12, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2 antagonistic activity, wherein L, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, R3 and n have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical compositions containing said compounds and to pharmaceutical compositions containing said compounds in combination with one or more active substances.