Inhibitors of the renal outer medullary potassium channel

US9206199B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Barbara Pio · West Orange, US
• Alexander Pasternak · Brookline, US
• Aurash Shahripour · Rahway, US
• Haifeng Tang · South San Francisco, US
• Shawn P. Walsh · Bound Brook, US

Key dates

• Filing date: Dec 11, 2012
• Grant date: Dec 8, 2015
• Expiry date: Dec 11, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula Iand the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.