N-substituted indenoisoquinolines and syntheses thereof

US9217010B2 · kind B2 · utility

Assignees

• Purdue Research Foundation · US
• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Mark S. Cushman · West Lafayette, US
• Andrew E. Morrell · San Diego, US
• Muthukaman Nagarajan · Hyderabad, IN
• Yves G. Pommier · Bethesda, US
• Keli K. Agama · Bowie, US
• Smitha Antony · Silver Spring, US
• Daniel Edward Beck · West Palm Beach, US

Key dates

• Filing date: Jul 24, 2014
• Grant date: Dec 22, 2015
• Expiry date: Jul 24, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J73/003
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof.