2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases

US9242988B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Vinay M. Girijavallabhan · Woburn, US
• Stephane L. Bogen · Somerville, US
• Weidong Pan · Somerville, US
• Qun Dang · Westfield, US
• Ian Davies · Princeton, US

Key dates

• Filing date: Oct 11, 2013
• Grant date: Jan 26, 2016
• Expiry date: Oct 11, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65744
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula (I) are disclosed, wherein R1, R2, R3, R4, R5, and R18 are defined herein. The compounds encompassed by Formula (I) include compounds which are HCV NS5B inhibitors and other compounds which can be metabolized in vivo to HCV NS5B inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.